Crushing or chewing the tablets will destroy the extended-release properties of the drug. It is important to note however that split tablet should be swallowed whole, without chewing or crushing. The diagram below shows the inside of metoprolol ER tablets, showing the pellets that each contain the active ingredient (metoprolol): Each pellet acts as a separate drug delivery unit, which allows the tablet to be cut in half as the pellets will be unaffected with one cut. This is not the case for metoprolol ER (generic for Toprol-XL), however.Įach Metoprolol ER tablet contains a large number of tiny controlled release pellets, which are evenly dispersed throughout the tablet. Metoprolol ER Release Mechanismįor most extended-release medications, altering the tablet/capsule will destroy the extended-release mechanism, causing the entire dose to be delivered at once, which can increase the risk of overdose and side effects. In fact, the tablets have a 'score' line, and the drug is one of the few extended-release medications that are able to be cut safely due to how the extended-release mechanism of metoprolol succinate works. Drug disposal: drug take back locations.Thanks for contacting us! Yes, Toprol XL (metoprolol succinate extended-release) can be cut or split in half. Metoprolol tartrate - drug summary.įood and Drug Administration. High blood pressures and symptoms.Īmerican Heart Association. doi:10.1136/bmj.f55Ĭenters for Disease Control and Prevention. Benefits of β blockers in patients with heart failure and reduced ejection fraction: network meta-analysis. FDA identifies harm reported from sudden discontinuation of opioid pain medicines and requires label changes to guide prescribers on gradual, individualized tapering.Ĭhatterjee S, Biondi-zoccai G, Abbate A, et al. Metoprolol: a review of its use in chronic heart failure. Lopressor HCT (metoprolol tartrate and hydrochlorothiazide) prescribing information. Toprol-XL (metoprolol succinate) prescribing information.įood and Drug Administration. Label: Lopressor- metoprolol tartrate tablet.įood and Drug Administration. Types of blood pressure medications.ĭailyMed. Beta-blockers.Īmerican Heart Association. Comprehensive comparative effectiveness and safety of first-line β-blocker monotherapy in hypertensive patients: a large-scale multicenter observational study. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Label: metoprolol succinate- metoprolol succinate er tablets tablet, film coated, extended release. Control of blood pressure: Beta-blockers are commonly used to help lower blood pressure in combination with other medicines, such as an ACE inhibitor, or a calcium channel blocker.ĭailyMed.Protection against recurrent heart attacks: In people who have had a heart attack, beta-blockers help reduce the risk of heart attacks in the future.These drug symptoms caused by AF, particularly palpitations and fatigue, are often improved by slowing the heart rate. Treatment of some heart rhythm disorders: Beta-blockers control irregular heart rhythm in people with atrial fibrillation (AF).Beta-blocker works with angiotensin-converting enzyme (ACE) inhibitors, for example, Altace (ramipril), and in many cases, an aldosterone inhibitor. Treatment of heart failure: Beta-blockers improve life expectancy in people with heart failure caused by impaired contraction of the left ventricle (the main pump chamber of the heart).Treatment of angina: By reducing the heart rate, beta blockers are used as first-line treatment in people with angina, either alone or in combination with a calcium channel blocker.
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